Altogen Labs is a premier provider of preclinical research services, dedicated to supporting the pharmaceutical, biotechnology, and academic communities with high-quality and customized solutions. Our state-of-the-art research laboratory located in Austin (Texas), experienced scientific team, and stringent quality control measures enable us to deliver accurate, reproducible, and actionable data for drug discovery and development.
1. Xenograft Models
Altogen Labs specializes in creating patient-derived xenograft (PDX) and cell line-derived xenograft (CDX) models to evaluate the efficacy of anti-cancer therapeutics. These models are instrumental for studying tumor growth, metastasis, and response to treatment in vivo:
List of over 90 in-house validated xenograft models: Link
- Subcutaneous Xenograft Models: Simplified tumor growth studies that allow for easy monitoring of tumor size.
- Orthotopic Xenograft Models: Tumor implantation at the organ of origin to better mimic the tumor microenvironment.
- Metastasis Models: Advanced models for studying cancer progression and drug effects on metastatic disease.
2. RNA Interference (RNAi) Services
Our RNAi research services include the design, synthesis, and validation of RNAi-based tools to modulate gene expression effectively.
- siRNA and shRNA Design: Optimized for maximum target gene silencing and minimal off-target effects.
- In Vivo Delivery Systems: Lipid nanoparticles, viral vectors, and other advanced delivery systems.
- Functional Validation: Quantitative PCR and Western blot analysis for precise efficacy evaluation.
3. CRISPR Gene Editing
Altogen Labs provides comprehensive CRISPR/Cas9 gene editing services, enabling precise modifications of target genes.
- Gene Knockout and Knock-in Models: Custom-built models for understanding gene function.
- CRISPR Library Screening: High-throughput screening to identify genes critical for drug resistance or other cellular phenotypes.
- Validation and Off-target Analysis: Ensuring specificity and accuracy of genetic edits.
4. Pharmacology Studies
Our preclinical pharmacology services support drug discovery pipelines with a focus on pharmacokinetics (PK) and pharmacodynamics (PD): altogenlabs.com/pre-clinical-research-services/pharmacology-and-toxicology-testing-ic50-for-tumor-cell-lines
- PK/PD Modeling: Determination of drug absorption, distribution, metabolism, and excretion (ADME).
- Dose-Response Studies: Identifying the optimal therapeutic window.
- Toxicity and Safety Evaluation: Early-stage assessments to minimize downstream risks.
5. Cell Line Development and Assays
Altogen Labs offers cell line engineering and assay development tailored to the client’s specific research needs: altogenlabs.com/pre-clinical-research-services/elisa-and-cell-based-assay-development-cell-cycle-viability
- Stable Cell Line Development: Generation of cell lines expressing target proteins, reporters, or CRISPR components.
- High-Throughput Screening Assays: Assays for drug screening, including proliferation, cytotoxicity, and apoptosis.
- 3D Cell Culture Models: Spheroid and organoid cultures to mimic in vivo environments.
6. Toxicology Studies
Our toxicology services include both in vitro and in vivo assessments to evaluate drug safety profiles: altogenlabs.com/biology-laboratory-cro-services/in-vivo-toxicology-service
- Cytotoxicity Testing: MTT, LDH, and live/dead assays for cell viability.
- Genotoxicity Studies: Micronucleus and comet assays for DNA damage evaluation.
- Chronic and Acute Toxicity Studies: Long-term safety studies in animal models.
7. Molecular Biology Services
Altogen Labs offers an extensive suite of molecular biology services to support basic and applied research: altogenlabs.com/pre-clinical-research-services
- PCR and qPCR: Gene expression analysis with high sensitivity and specificity.
- Next-Generation Sequencing (NGS): Comprehensive genome, transcriptome, and epigenome analysis.
- Western Blot and ELISA: Protein quantification and analysis.
8. Custom Research Projects
We understand that each research project is unique. Altogen Labs collaborates closely with clients to design and execute custom studies.
- Feasibility Studies: Early-stage assessments for novel drug candidates.
- Mechanism of Action (MOA) Studies: Elucidating how a drug interacts with its target.
- Biomarker Discovery: Identification and validation of predictive and prognostic biomarkers.
Why Choose Altogen Labs?
- Expertise: A team of highly skilled scientists with deep expertise in preclinical research.
- Customization: Flexible study designs tailored to specific project goals.
- Cutting-edge Technology: Utilization of advanced techniques and equipment.
- Timely Results: Efficient workflows to meet tight deadlines without compromising quality.
- Regulatory Compliance: Adherence to GLP guidelines and ethical standards.
Altogen Labs is committed to accelerating the pace of scientific discovery and bringing innovative therapeutics to patients. For more information about our services or to discuss your research needs, please visit our website www.altogenlabs.com